Organ-on-Chip Platforms Inform Diabetes Research

The Salem Lab, based out of Imperial College London's South Kensington Campus, is at the forefront of Organ-on-Chip research. Our team is dedicated to revolutionizing the field of diabetes research and treatment through the use of tissue engineering and regenerative medicine technologies.

Our Research Focus

The Salem Lab is committed to advancing the frontiers of islet biology and bioengineering in the context of type 1 diabetes. Our interdisciplinary approach allows us to collaborate with other field leaders, with a focus on developing solutions that have the potential to transform patient care and treatment outcomes. Our team is passionate about driving positive change through scientific discovery and collaboration.

News & Events

Check back soon

Once posts are published, you’ll see them here.

Latest Publications

Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis

Beta-cell selective loss of the glucagon receptor (Gcgrβ-cell−/−) results in defective insulin secretion. Gcgrβ-cell−/− islets display reduced ability for calcium waves to propagate and reduced beta-cell connectivity. Long-term glucagon therapy reverts the loss of beta-cell calcium waves and dysglycaemia associated with diet induced obesity.